RAF Typhoon FGR4s have operated alongside French aircraft in a combined operation against an subterranean weapons facility in Syrian territory employed by the IS group, according to the UK's MoD.
The location, identified by surveillance, was thought to be storing arms and explosives, the announcement noted, and was situated in hills just to the north of the historic site of Palmyra in the heart of Syria.
"The RAF jets used Paveway IV guided bombs to hit a several approach shafts leading to the site... preliminary assessments indicate the strike was effective," the MoD said.
There was no evidence of any civilian casualties in the attack late on Saturday and all the aircraft returned to base without incident, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager tanker plane.
IS - referred to as Daesh - established militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action shows the UK's leading role, and determination to operate in unison with allied nations, to stamp out any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey remarked.
British military aircraft have carried out patrols over Syrian airspace to "prevent any attempted comeback" of Islamic State following its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I must thank every member of the UK armed forces who took part in this strike for their skill and their bravery," Healey said. "They were part of thousands of British personnel stationed over the festive period. This mission, to remove militants who threaten our way of life, shows how UK forces are always on standby, throughout the year, keeping Britain secure within its borders and strong abroad."
During December, the United States armed forces conducted what it described as a "large-scale strike" on Daesh sites in the country, after an ambush claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The U.N. says Islamic State still boasts roughly 5-7 thousand militants in Iraq and Syria.
